Qwixx Longo is a quick-playing dice game in which everyone participates, no matter whose turn it is. Gameplay is nearly identical to 2012's Qwixx, but with eight-sided dice allowing for higher numbers to be rolled and lucky numbers that give additional chances to mark off spaces.

Each player has a scoresheet with the numbers 2-16 in rows of red and yellow and the numbers 16-2 in rows of green and blue. To score points you want to mark off as many numbers as possible, but you can mark off a number only if it's to the right of all marked-off numbers in the same row.

On a turn, the active player rolls six eight-sided dice: two white and one of each of the four colors listed above. Each player can choose to mark off the sum of the two white dice on one of their four rows; additionally, if the sum of the white dice matches one of the two lucky numbers printed on your scoresheet, you immediately mark off the next number in the row in which you have the fewest marks.

Then the active player can choose to mark off the sum of one colored die and one white die in the row that's the same color as the die. The more marks you can make in a row, the higher your score for that row. Fail to cross off a number when you're the active player, however, and you must mark one of four penalty boxes on your scoresheet. If you have at least six numbers marked in a row, then you can mark off either of the final two spaces in a colored row (15/16 in red/yellow and 3/2 in green/blue) — assuming the dice allow you to do so, of course. If you do this, you also mark off the padlock symbol in that row, locking everyone else out of this color.

When either a player has four penalty boxes marked or a second color is locked, the game ends immediately. Players then tally their points for each color, sum these values, then subtract five points for each marked penalty box. Whoever has the highest score wins.